ea0022oc4.4 | Adrenals | ECE2010
Kamenicky Peter
, Droumaguet Celine
, Baudin Eric
, Salenave Sylvie
, Trabado Severine
, Cazabat Laure
, Chanson Philippe
, Young Jacques
Context: Mitotane due to its adrenolytic action is highly effective in long-term management of ACTH-dependent Cushings syndrome (CS). However, the slow onset of its anticortisolic effect makes its use problematic in severe CS, when very rapid therapeutic response is required. Association with metyrapone and ketoconazole, rapidly acting steroidogenesis inhibitors, could warrant CS control while waiting for the full efficiency of mitotane and thus avoid urgently performed ...